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In diabetes and obesity, accelerated formation of an enlarged necrotic core is likely instigated by defective macrophage insulin signaling (176) and saturated fatty acids (177,178), which are potent inducers of ER stress

If prescribed, medication, syringes, alcohol pads, and instructions are provided as part of the program

Because the first dose is typically a low loading dose (0.25 mg), the body is being gently introduced to the medication to minimize stress on the digestive system

Medication selection is personalized after clinical evaluation

However, genetic predispositions do not predict exact medication response or guarantee freedom from side effects